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| Section | Objectives |
|---|---|
| Topic 1: Physician Roles (CanMEDS Framework) | - Collaborator
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NEW QUESTION # 174
A 35-year-old woman, gravida 3, para 0, aborta 3, presents with her male partner because she has been unable to conceive despite trying for more than 1 year. Her menstrual cycles have been absent for 9 months, and she has occasional mild cyclic pain. She has a medical history of 3 suction curettages. Her BMI is 24.
Investigation results are as follows:
Hysterosalpingogram: Obliterated uterine cavity, no tubal dye spill
Progesterone (midluteal): 48.0 nmol/L (16.4-59.0)
Partner's semen: All parameters normal
Which one of the following is the most likely diagnosis?
Answer: B
Explanation:
This patient has secondary amenorrhea, infertility, and a history of multiple uterine curettages, which strongly points toward Asherman syndrome (intrauterine adhesions or synechiae). The hysterosalpingogram shows an obliterated uterine cavity and no tubal dye spill-classic for intrauterine synechiae. Her midluteal progesterone level is normal, indicating ovulation.
Toronto Notes 2023 - Gynecology, "Infertility" section:
"Asherman syndrome results from intrauterine adhesions due to curettage, leading to amenorrhea and infertility. HSG shows an obliterated or irregular uterine cavity." MCCQE1 Objectives (Gynecology > 82-1: Infertility):
"Candidates should evaluate secondary amenorrhea and interpret imaging such as hysterosalpingogram in the diagnosis of intrauterine abnormalities." Other options are ruled out by the presence of normal ovulation (rules out hypothalamic and PCOS) and by imaging (not suggestive of fibroids or perimenopause).
NEW QUESTION # 175
A 12-year-old boy is brought by his mother to your clinic with a history of attention-deficit/hyperactivity disorder. His mother reports that he has been taking immediate-release methylphenidate for 2 years. Although the medication was initially effective, it no longer seems to work. The teachers say he is disorganized and fidgety, verbally interrupts class, and does not complete his work. His mother tells you that he does listen at home. Which one of the following is the most important next step in management?
Answer: D
Explanation:
Management of ADHD requires ongoing reassessment using standardized rating scales from multiple informants (e.g., parents and teachers) to evaluate symptom control and functional impairment across settings.
This child demonstrates persistent school-related symptoms despite prior response to immediate-release methylphenidate. Before adjusting therapy, it is essential to objectively reassess symptom severity, adherence, timing of doses relative to school hours, and potential environmental factors. Completion of validated rating scales helps determine whether symptoms remain clinically significant and guides appropriate dose titration.
Stimulant medications such as methylphenidate are first-line treatment, and inadequate response often requires dose optimization before switching agents. Simply increasing the dose without reassessment is not best practice. Risperidone is not indicated for uncomplicated ADHD. An EEG is unnecessary unless there are seizure concerns. Switching to atomoxetine is premature without confirming inadequate response to optimized stimulant therapy. MCCQE objectives emphasize systematic monitoring, multi-informant assessment, dose titration, and evidence-based pharmacologic management in pediatric ADHD.
NEW QUESTION # 176
A 16-year-old girl is brought to the Emergency Department with a 12-hour history of worsening right lower quadrant abdominal pain and nausea. She is in no distress and vital signs are normal. Her abdomen is soft but locally tender in the right iliac fossa, and bowel sounds are active. White blood cell count is 7.6 × 10#/L (4-
10), C-reactive protein is 2.3 mg/L ( < 10) and serum beta human chorionic gonadotropin is undetectable.
Ultrasound reveals a small amount of fluid in the pelvis, and the appendix is not clearly apparent. Which one of the following is the best next management step?
Answer: B
Explanation:
This adolescent presents with possible early appendicitis but currently has mild clinical findings, normal vital signs, normal white blood cell count, and low CRP. Ultrasound does not visualize the appendix and shows only minimal pelvic fluid, which can be physiologic in adolescent females. According to MCCQE surgical objectives, when the diagnosis of appendicitis is uncertain and the patient is clinically stable, the preferred approach is observation with serial abdominal examinations rather than immediate imaging with CT or operative intervention.
CT scanning exposes a young patient to ionizing radiation and is not indicated when clinical suspicion is low to moderate and the patient is stable. Immediate appendectomy is inappropriate without stronger clinical or laboratory evidence. Empiric IV antibiotics are reserved for confirmed or strongly suspected appendicitis.
Serial radiography has no role in diagnosing appendicitis.
Careful monitoring over 12-24 hours allows progression of signs if appendicitis is present, improving diagnostic accuracy while avoiding I have cross-referenced your exam scores with NVIDIA's official technical documentation for **DGX H100
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### **Batch 1: Questions 1 - 5
NEW QUESTION # 177
A 29-year-old woman presents to the sexually transmitted infection clinic with concerns regarding a copious vaginal discharge. Ten percent potassium hydroxide was used to confirm the diagnosis of which one of the following?
Answer: C
Explanation:
A 10% potassium hydroxide (KOH) preparation is commonly used in the evaluation of vaginal discharge. In bacterial vaginosis (BV) , adding KOH to a vaginal sample produces a characteristic "whiff test" -a strong fishy amine odor caused by volatilization of amines from anaerobic bacteria (e.g., Gardnerella vaginalis and other anaerobes). MCCQE objectives emphasize recognition of BV as the most common cause of abnormal vaginal discharge in reproductive-age women. Clinical features include thin, gray-white, malodorous discharge without significant inflammation.
KOH microscopy may also reveal clue cells (vaginal epithelial cells coated with bacteria).
Trichomonas vaginalis is diagnosed by saline wet mount showing motile trichomonads or by nucleic acid amplification testing (NAAT), not primarily by KOH. Chlamydia trachomatis and gonorrhea are diagnosed by NAAT. Group B streptococcus is identified by culture.
Thus, use of 10% KOH to confirm a fishy odor (positive whiff test) supports the diagnosis of bacterial vaginosis .
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NEW QUESTION # 178
A 6-year-old girl is found to have a blood pressure of 130/75 mm Hg. She was born prematurely at 32 weeks' gestation and required ventilation. There is a family history of hypertension in 3 grandparents. Clinical examination reveals a grade 1/6 mid-systolic murmur, no renal bruits, and femoral pulses are difficult to feel.
Which one of the following is the most likely diagnosis?
Answer: E
Explanation:
Comprehensive and Detailed Explanation:
The combination of upper extremity hypertension and weak femoral pulses is classic for aortic coarctation. A soft systolic murmur may be present. This condition often becomes apparent during routine screening in school-aged children.
Toronto Notes 2023 - Pediatrics / Cardiology:
"Coarctation of the aorta presents with upper limb hypertension, diminished femoral pulses, and sometimes a systolic murmur. BP discrepancy is key." MCCQE1 Objectives (Pediatrics > 78-1: Congenital Heart Disease):
"Candidates must recognize signs of aortic coarctation, including weak lower limb pulses and systemic hypertension in children." VSD (A) typically presents with a louder murmur. Reflux nephropathy (B) may cause hypertension but without femoral pulse discrepancy. Renal artery thrombosis (C) is rare. Essential hypertension (D) is less likely in this age group with these findings.
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NEW QUESTION # 179
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