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| Section | Objectives |
|---|---|
| Topic 1: Physician Activities | - Assessment
|
| Topic 2: Dimensions of Care | - Acute Care
|
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NEW QUESTION # 188
A 62-year-old woman is taken to the operating room for an elective laparoscopic cholecystectomy. Induction of anesthesia triggers a severe hypertensive crisis that ultimately resolves after administration of a 5 mg bolus of phentolamine.
Which one of the following is most consistent with this presentation?
Answer: C
Explanation:
This presentation is classic for an undiagnosed pheochromocytoma, which causes episodic or crisis-level hypertension due to excess catecholamines. Anesthesia or surgical manipulation can trigger massive catecholamine release, leading to hypertensive crisis. Phentolamine, an alpha-blocker, is the appropriate treatment.
Toronto Notes 2023 - Endocrinology, Pheochromocytoma:
"Pheochromocytomas may precipitate hypertensive crises during surgery. Elevated plasma catecholamines and urinary metanephrines confirm diagnosis." MCCQE1 Objectives - Internal Medicine > Endocrinology:
"Candidates should suspect pheochromocytoma in perioperative hypertensive crises and confirm with plasma or urine catecholamines/metanephrines." Low metanephrines (E) would argue against pheochromocytoma. TSH (A), cortisol (D), and renin (C) are unrelated to acute intraoperative hypertensive episodes of this nature.
NEW QUESTION # 189
A 4-year-old boy is brought by his parents to your walk-in clinic with a 3-week history of fatigue, bruising, and intermittent fever. He was previously healthy. Physical examination reveals hepatosplenomegaly and petechiae. His complete blood count shows the following:
Platelet count, blood: 15.0 × 10#/L (206.4-443.3)
White blood cell (WBC) count, blood: 1.0 × 10#/L (4.7-13.5)
Hemoglobin (Hgb), blood: 70 g/L (105-135)
Which one of the following is the most likely diagnosis?
Answer: E
Explanation:
This child has pancytopenia (severe thrombocytopenia, leukopenia, and anemia) plus systemic symptoms (fatigue, intermittent fever) and hepatosplenomegaly, strongly suggesting bone marrow failure/infiltration, most commonly acute lymphoblastic leukemia (ALL) in this age group. MCCQE objectives emphasize recognizing red flags for childhood malignancy: unexplained bruising/petechiae from thrombocytopenia, recurrent or persistent fever, pallor, and organomegaly due to leukemic infiltration or extramedullary hematopoiesis.
Immune thrombocytopenia typically causes isolated thrombocytopenia with otherwise normal hemoglobin and WBC count and usually no hepatosplenomegaly. Iron deficiency anemia causes microcytic anemia but does not explain profound thrombocytopenia and leukopenia. Viral illness may transiently suppress counts but is less likely to cause marked pancytopenia with significant organomegaly. Bacterial sepsis can cause thrombocytopenia but usually presents with acute toxicity and does not typically produce this pattern of sustained pancytopenia and hepatosplenomegaly.
Next steps (clinically) would include urgent peripheral smear, oncology referral, and bone marrow evaluation.
NEW QUESTION # 190
A 38-year-old woman presents with diffuse nodularity in the outer upper quadrant of her right breast. There is no obvious dominant mass, nipple discharge, or skin dimpling. There are no palpable lymph nodes. Which one of the following is the most likely diagnosis?
Answer: B
Explanation:
Fibrocystic change is the most common benign breast condition in women of reproductive age. It typically presents with diffuse nodularity or "lumpy" areas, especially in the upper outer quadrant, and varies with the menstrual cycle. No dominant mass or systemic signs are expected.
Toronto Notes 2023 - Gynecology, "Benign Breast Conditions":
"Fibrocystic changes often present with bilateral or unilateral nodularity, most commonly in the upper outer quadrants, without discrete masses." MCCQE1 Objectives (Gynecology > 81-1: Breast Conditions):
"Candidates must differentiate benign breast conditions from malignant ones based on presentation and physical exam findings." Paget disease (B) presents with nipple changes. Intraductal carcinoma (C) typically shows a discrete mass or suspicious features. Phyllodes tumours are usually well-circumscribed. Mastitis (E) is inflammatory and associated with erythema, fever, and tenderness.
NEW QUESTION # 191
Which one of the following bodies decides whether a physician is permitted to practise medicine in a province or territory?
Answer: B
Explanation:
Comprehensive and Detailed Explanation:
The authority to license and regulate physicians to practise medicine is held by the medical regulatory colleges in each province or territory (e.g., CPSO in Ontario, CPSBC in BC).
MCC Objectives (ELOM > 90-1: Medical Regulation in Canada):
"Licensure to practise medicine is granted by the provincial or territorial medical regulatory authority." Toronto Notes 2023 - Ethics and Canadian Health Care System:
"Medical regulatory colleges determine physician licensure and discipline in each jurisdiction." The CFPC/RCPSC (C) certify physicians, not license them. Ministries of Health (A) oversee health policy, not licensing. Associations (E) advocate for physicians but do not regulate. Hospital boards (B) grant privileges, not licenses.
NEW QUESTION # 192
A 23-year-old woman with borderline personality disorder is brought to the Emergency Department having ingested non-lethal substances after her boyfriend broke up with her. The staff tells you that she has consulted
8 times under similar circumstances in the past 3 years. Which one of the following pieces of information would be useful to provide to the staff?
Answer: D
Explanation:
Comprehensive and Detailed Explanation:
While borderline personality disorder is challenging, symptoms (particularly impulsivity and suicidal behaviors) often attenuate with age and appropriate therapy (e.g., dialectical behavior therapy). Providing hope and clinical context to staff improves care and reduces stigma.
Toronto Notes 2023 - Psychiatry, "Personality Disorders":
"BPD is associated with emotional dysregulation and impulsivity. Long-term prognosis is better than once believed, with many patients showing symptom remission over time." MCCQE1 Objectives (Psychiatry > 71-4: Personality Disorders):
"Candidates must provide appropriate education to patients and staff regarding prognosis and treatment of BPD." Statements A-D are false, stigmatizing, or dangerous.
NEW QUESTION # 193
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